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Requires a medical diagnosis Infections, pain and fatigue are symptoms of sickle cell disease. People may experience: Pain areas: in the joints Pain types: can be sudden in the chest Whole body: dizziness, fatigue, low oxygen in the body, or malaise Urinary: inability to make concentrated or dilute urine or blood in urine Also common: abnormal breakdown of red blood cells, inflamed fingers or toes, pallor, shortness of breath, or yellow skin and eyes Requires a medical diagnosis Infections, pain and fatigue are symptoms of sickle cell disease. People may experience: Pain areas: in the joints Pain types: can be sudden in the chest Whole body: dizziness, fatigue, low oxygen in the body, or malaise Urinary: inability to make concentrated or dilute urine or blood in urine Also common: abnormal breakdown of red blood cells, inflamed fingers or toes, pallor, shortness of breath, or yellow skin and eyes